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A model of diabetic neuropathy caused by streptozotocin in rats has shown the neuroprotective properties of GLP-1RA semaglutide by reducing inflammation and oxidative stress by inhibiting the activity of astrocytes and microglia [32]
Irish Medicines Board
Food-induced lowering of blood-ethanol profiles and increased rate of elimination immediately after a meal
These findings confirm the fundamental role played by GLP-1 in the treatment of obesity and T2D, but suggest the need for further investigation of its exact mechanisms of action, as well as of possible differential effects of circulating levels of GLP-1 and administration of GLP-1R agonists
[PMC free article: PMC3683201] [PubMed: 23776899] 66
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