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coli Nissle 1917 ( Ec N) to efficiently convert L-tyrosine, the substrate from which p-cresol, the precursor for the uremic toxin p-CS is derived from to p-coumaric acid which is a non-toxic compound via tyrosine ammonia lyase

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This gender difference could be due to the antioxidant properties of oestrogen, which reduces the number of superoxide anions and results in less endothelial dysfunction in females ( Reference Dantas, Tostes and Fortes 24 , Reference Salonen, Salonen and Penttila 25 )

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