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In the circulation, VLDL is metabolized to the cholesteryl ester-enriched intermediate low-density lipoprotein (IDL) and LDL particles through the progressive hydrolysis of triglycerides by lipoprotein lipase (LPL) and hepatic lipase (Figure 6)
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Severe hepatic impairment lacks adequate safety data, making tirzepatide use in these patients rely on careful individual benefit risk assessment
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