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Nat Rev Neurosci 14:311321 Pekny M, Nilsson M (2005) Astrocyte activation and reactive gliosis

Effective transdermal delivery would require advanced technologies such as: Microneedle arrays : Tiny needles that create microscopic channels in the skin to facilitate drug absorption (these are minimally invasive devices rather than traditional patches) Chemical penetration enhancers : Substances that temporarily increase skin permeability Iontophoresis : Using electrical currents to drive charged molecules through the skin Nanoparticle formulations : Encapsulating drugs in carriers designed to cross skin barriers Several preclinical and early-stage studies have explored these approaches for GLP-1 delivery, with some promising results in laboratory and animal models

Chen L, Zhang S, Duan Y, Song X, Chang M, Feng W, et al

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