Shortcomings of Animal Models : While preclinical data can be suggestive, they do not always accurately predict clinical outcomes in humans due to differences in physiology, disease progression, and complex metabolic interactions that cannot be fully replicated in animal models
Keywords: Metformin, type 2 diabetes, GLP-1 receptor agonists, SGLT2 inhibitors, diabetes guidelines, cardiovascular outcomes 1
It has been demonstrated that obesity-associated induction of MT expression in adipose tissue is a protective response, being at least partially mediated through modulation of oxidative and endoplasmic reticulum stress [62]
Systematic review of the relationships between sleep duration and health indicators in school-aged children and youth
The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss