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Canonically, NETosis proceeds through a highly orchestrated series of intracellular events involving chromatin decondensation, histone citrullination mediated by peptidylarginine deiminase 4 (PAD4), and the translocation of neutrophil elastase (NE) and MPO from cytoplasmic granules into the nucleus, culminating in the extrusion of DNAprotein complexes into the extracellular space [45, 46]

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We observed no effect measure modification after stratifying patients by history of renal disease (supplementary table M)