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Once steady state is reached, the amount coming in with each dose equals the amount being cleared

This unexpected observation led to a model where a low number or density of methylated CGs would not repress gene transcription (Weber et al., 2007

So, if your vitamin B12 is not working properly because your folate metabolism isnt working properly this causes homocysteine imbalances which are considered a serious health problem for anyone especially for those with MTHFR gene mutations. 4 Reactions to Methylfolate supplementation Individuals that cannot tolerate Methylfolate often have low B12 levels in their cells

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