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Taken together, our findings suggest that hydropersulfides (and/or other S 0 species derived from hydropersulfides) can act as direct oxidant scavengers already at low concentrations (as reflected by the suppression of H 2 O 2 -induced roGFP2-Orp1 or MitoPY1 oxidation), and additionally as inducers of protein hydropersulfidation, which however seems to require higher concentrations (as reflected by the induction of roGFP2 oxidation)
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Thus, deficiencies in L-carnitine or its transporter CAC have particularly adverse effects on cardiomyocytes, resulting in cardiomyopathy, cardiac arrhythmia, cardiac insufficiency, and heart failure [4]
Low levels of vitamin B12 have also been associated with neuronal degeneration in other models (Moore 2012)
Fortunately, in most individuals, these symptoms are temporary and can be remedied with a few practical lifestyle changes
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