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Renal function and volume-sensitive medicines: Prolonged vomiting or diarrhoea can cause dehydration and may impair kidney function, particularly in people taking ACE inhibitors, angiotensin receptor blockers (ARBs), or diuretics

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These changes extend the medication's half-life from minutes to approximately one week, enabling once-weekly dosing rather than multiple daily injections

Effect of ertugliflozin on blood pressure in patients with type 2 diabetes mellitus: a post hoc pooled analysis of randomized controlled trials

As of this writing, retatrutide is in late-stage clinical trials but has not received FDA approval