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What is worth emphasizing, in the study by Zakharov et al., 47% of deaths were associated with the occurrence of neoplastic, which was probably related to the carcinogenic effect of acute exposure to methanol and its metabolites, especially formaldehyde, and secondary, significantly increased oxidative stress (Zakharov et al
Eur J Biochem 133:5169
Also, if there are low levels of cysteine in cells during times of oxidative stress, this may limit their ability to make their own glutathione
This timing is not arbitrary
Subsequent chromatin immunoprecipitation assay (ChIP) showed that NRF2 binds to the locus but not the downstream exon 7 region (Fig
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