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Semaglutide and tirzepatide are "upstream" they act on incretin receptors to influence appetite regulation, gastric emptying, and glucose-dependent insulin secretion

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For example, in a randomized controlled trial involving 7,062 heart attack patients, the incidence of major adverse cardiovascular events during a median of three years of follow-up was not significantly different in those who received low-dose colchicine as part of treatment compared with those who received placebo