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CENTRAL GREAT PLAINS Ifeanyi Chukwudi Achugbu University of Nebraska-Lincoln Irrigation modifies land-atmosphere interactions by altering surface fluxes, boundary-layer thermodynamics, and moisture transport, yet its influence on precipitation remains highly regime dependent

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This circuit has been shown in breast cancer (METTL3IGF2BP3), bladder cancer (JNKMETTL3IGF2BP1), and intrahepatic cholangiocarcinoma (where ALKBH5 demethylation maintains PD-L1), with mechanistic interventions reversing immune evasion phenotypes and, in some settings, sensitizing tumors to anti-PD-1 therapy