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Funding This work was supported by the National Natural Science Foundation of China (Grant Number 81870257 and 31871172) and Key Research and Development Program of Shaanxi (Grant Number 2021SF-132)

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Therefore, by activating this NCOA4-mediated ferritinophagy pathway, Erastin promotes the release of free iron, which in turn amplifies ROS production and lipid peroxidation, resulting in an autophagy-dependent mode of ferroptosis