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ACS Pharmacol and translational Sci (2024) 7(5):127890
Incompatible ingredients requiring separation include vitamin C (use morning versus evening rather than together), strong exfoliating acids (alternate nights rather than same routine), and retinoids (can be combined carefully but may increase irritation, alternating nights often works better)
10.1046/j.1471-4159.2001.00188.x 7 AppelS
This can result in higher bioavailability and more immediate effects compared to oral supplementation
You might fall asleep faster, but deep sleep and REM sleep are both significantly reduced
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