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4.3.2 Case studies of antioxidants used alongside chemotherapeutic agents Table 1 shows a summary of the selected cases on combining antioxidants and chemotherapy drugs

While some patients report less nausea or improved energy, these findings are largely anecdotal and based on small-scale observational data

Given that serotonin synthesis pathways are similar between the brain and periphery and across mammalian species, we here examine in humans the following hypotheses in both CFS and hypothyroidism with fatigue: (1) serum serotonin (S-5-HT) levels are low, (2) L-carnitine supplementation is associated with increased S-5-HT levels and reduced fatigue, and (3) there exists a correlation between peripheral S-5-HT and fatigue levels