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In PD, along with -synuclein accumulation, there is associated inflammation, synaptic dysfunction, dopaminergic neuronal loss, and some data to suggest insulin resistance

The second generation somatostatin analog pasireotide has been shown to induce impaired glucose tolerance, overt diabetes or worsen glycemic control especially in patients with pre-existing disturbed glucose metabolism (52)

Thats up 80% since 2024

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