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(2010) J Biol Chem 285 : 22152-22163 PubMed: 20463020 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 3HS5, 3HS6, 3HS7, 3KRK PubMed Abstract: The cyclooxygenases (COX-1 and COX-2) are membrane-associated heme-containing homodimers that generate prostaglandin H(2) from arachidonic acid (AA)

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Newer compounds like retatrutide act on three receptors simultaneously (GLP-1, GIP, and glucagon), combining appetite suppression with increased energy expenditure

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