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All the WT-AIM interactions with DAMPs exhibit Ca 2+ concentration dependence, and mutating the two aspartic acid residues (D270A and D271A) abrogates the binding for all the cases, suggesting the indispensability of the first calcium site
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Clinical trials with GLP-1 receptor agonists consistently demonstrate significant weight loss, with higher doses (such as semaglutide 2.4 mg weekly) producing approximately 15% average weight loss in adults without diabetes in clinical trials (somewhat less in type 2 diabetes) when combined with lifestyle modification
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