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Unrepaired 8-oxo-G is potentially one of the most mutagenic lesions, since it pairs with A, inducing G T transversions 40 , and represents a prominent candidate to be a marker of ROS-induced mutagenesis and tumorigenesis 41

The SELECT trial showed that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in people with overweight or obesity and established cardiovascular disease

Accordingly, a clinical trial evaluating the effect of weekly caloric reduction achieved with either caloric restriction or intermittent fasting in 29 overweight/obese individuals with ADPKD was recently completed (Hopp et al., 2021

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