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The keywords used in the literature search included design, synthesis, DPP-4 inhibitors, docking, and structure-activity relationship. Initially, 200 papers were evaluated, with duplicates and publications unrelated to the searchs objective discarded

In the coupling reaction, the iodinated tyrosine residues are combined by TPO to make triiodothyronine (T3) and tetraiodothyronine (T4), where MIT and DIT join to form T3, and two DIT molecules form T4

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One area of growing interest is the impact of NSAIDs on glutathione, a crucial antioxidant that plays a role in protecting the body from oxidative stress and supporting overall wellness