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When higher levels of acetaminophen are ingested, the livers supply of glutathione is depleted and NAPQI causes liver damage.[ref] Related article: Genetic variants that increase the risk of liver damage from acetaminophen Studies on the impacts of low glutathione levels: Glutathione levels in the body are fairly tightly regulated, and balance is key

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Anderson KA, Means RL, Huang QH, Kemp BE, Goldstein EG, Selbert MA, et al

Komulainen and Tuomisto, 1982)