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Influence of betalin-rich extracts on reduction of discomfort associated with osteoarthritis

Historically, transcription factors like C/EBP have posed therapeutic challenges due to their absence of enzymatic activity and well-defined small-molecule binding sites, rendering them difficult to target directly with traditional drugs (Hattori et al., 2003)

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Ruman in 1998 with isolation of pure compound (2 mg)