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Side effects with current GLP-1 drugs are attributed to the triggering of alternative pathways

[ 4 ] Instead, several hypotheses have been proposed based on preclinical investigations

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Under this perspective, as reported in a systematic analysis for the Global Burden of Disease Study 2021 [1, 2], the age-standardized rates of deaths per 100,000 individuals attributed to 37 unique conditions affecting the nervous system that now include neurodevelopmental disorders, late-life neurodegeneration, and emergent conditions such as cognitive impairment following coronavirus disease 2019 (COVID-19), has decreased by 33.6% from 1990 to 2021

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