glp 1 insulin secretion JCI Schematic of action of GLP-1

doi: 10.1371/journal.pone.0052965 Koludarov, Ivan, Sunagar, Kartik, Undheim, Eivind A

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[but, weve just assumed this was due to reduced intake] of dietary cholesterol and saturated fat But, what these researchers found was that within 24 hours of carnitine consumptioneating a sirloin steak, taking a carnitine supplementcertain gut bacteria metabolize the carnitine to a toxic substance called trimethylamine, which then gets oxidized in our liver to TMAO (trimethylamine-n-oxide), which then circulates throughout our bloodstream

These changes may result in segmental weakness of the artery, predisposing to rupture into the lumen

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