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The challenges and countermeasures of immunotherapy are similar to those for techniques such as chemotherapy, however, these combination approaches are advantageous in that they are able to be specifically designed, enabling them to counteract known side effects associated with treatment types

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The p62-Keap1-NRF2 pathway plays an important role in preventing ferroptosis in HCC cells, and the RAS/Raf/MEK pathway is an important target for the treatment of HCC 32,40