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Current studies have shown that 1) anomalous high SUA level is likely to induce a series of cardiovascular diseases, and acts as an independent risk factor for cardiovascular diseases, including atherosclerosis, hypertension, and coronary heart disease (Jingzhe Han et al., 2019)

These events have primarily occurred in patients who had pre-existing cardiovascular disorders or received other drugs that may have similar adverse cardiovascular effects

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doi:10.1016/j.procbio.2006.09.003 Zhang J, Quan C, Wang C, Wu H, Li Z, Ye Q (2016) Systematic manipulation of glutathione metabolism in Escherichia coli for improved glutathione production