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These enkephalins bind to opioid receptors in the gut, creating a potent, natural analgesic effect that can significantly reduce the severe abdominal cramping and visceral pain that many Long COVID and MCAS patients experience after eating

Other indications include malabsorption disorders (such as Crohn's disease or coeliac disease), following gastric surgery, strict vegan diets without supplementation, and certain medications that interfere with B12 absorption

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Nordlund JJ, Grimes PE, Ortonne JP

Theranostics, 2020, 10: 72737286 Li X, Pan Y, Chen C, et al