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doi: 10.1007/s10811-008-9390-9 141

Most patients notice a reduction in appetite within two to three weeks of starting medication

10.1016/j.celrep.2014.10.032 16 Da SilvaR

This accumulation ratio is important for understanding what happens when you stop: it takes longer to reach "zero" than the simple half-life calculation might suggest because you are clearing accumulated drug, not just the final dose