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Moreover, mitochondrial DAMPs released from stressed cells-such as mtDNA and cardiolipin-serve as potent activators of pattern recognition receptors (e.g., TLR9, cGAS-STING, and NLRP3), perpetuating inflammation (Mills et al., 2017)

Electrophysiology experiments further demonstrated that GLP-1R activation led to depolarization of POMC neurons and inhibition of NPY/AgRP neurons, mediated by GABAergic signaling, explaining the suppression of hunger signals

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S.BaxterM.et al

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