Last reviewed: June 6, 2026 Last updated: June 6, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
The other thing to consider, is that if you have an MTHFR gene mutation, you may be better off having methylated B12 supplement, which is an active form of B12 that the body does not have to convert and so you can use it more readily
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Dosage & Administration Typical adult dose: One spray (500 mcg) in one nostril once per week Administer at least 1 hour before or after eating hot food Use only as directed by your healthcare provider Each spray bottle contains multiple dosesfollow storage and usage instructions carefully Nascobal vs Oral or Injectable B12 Injectable B12 is effective but requires regular medical visits or self-injections Oral B12 may be poorly absorbed in those with GI disorders Nascobal provides reliable, direct absorption through nasal tissues with minimal discomfort Shipping & Availability We supply authentic, US-sourced Nascobal nasal spray and ship discreetly to: United Kingdom (UK) Australia Switzerland And other eligible countries Check our Country Restrictions page before ordering
Physiology 591, 45814593