And to be clear: GLP-1 medications are not FDA-approved for alcohol use disorder
Pharmacology of dipeptidyl peptidase-4 inhibitors: similarities and differences
However, the higher baseline HbA1c in the PIONEER 3 trial (8.31% in PIONEER 3 compared with 7.96% in PIONEER 4) was felt to be more aligned with target population in Portugal, and to correlate with the large reductions in HbA1c observed in the NMA with oral semaglutide 14 mg, and therefore the PIONEER 3 data were used in the base case analysis
At peak, compounded GLP-1 medications accounted for roughly 30% of US supply, according to published industry estimates, at prices of $150 to $300 per month versus $1,000-plus for brand-name versions
Fact: While production drops significantly with age, young adults facing high stress or environmental toxins can experience depleted levels long before they reach their senior years