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Description

Photoprotective and Antioxidant Signaling Consistent with MC1R engagement, MT-2 has been shown in in-vitro models to reduce UV-induced cyclobutane pyrimidine dimer (CPD) formation and attenuate reactive oxygen species (ROS) accumulation in melanocytes, paralleling the photoprotective signaling profile documented for MT-1 (Abdel-Malek et al., Cancer Research, 2005)

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However, for confirmed B12 deficiencyparticularly pernicious anaemia or neurological symptomsintramuscular hydroxocobalamin injections remain the first-line treatment in the UK, as recommended by NICE and the British Society for Haematology

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(2017) 7:a024240

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HbF, hemoglobin F

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10.1007/s00415-009-5100-z 24 BouzatP.SalaN.SuysT.ZerlauthJ

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