Long-term LC use can worsen gut dysbiosis by increasing the F/B ratio, resulting in increased TMAO formation and systemic inflammation as mentioned in Table 1
Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function
This guide pulls that experience together with published clinician ranges so you get one clear answer to how much, how often, and whether it does anything
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