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Discussion In this study, we demonstrated that inhibition of glucagon activity by GCGR mAb not only improved blood glucose control but also increased pancreatic beta cell mass and proliferation in mouse models of type 2 diabetes

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Add to this complexity the high cost of making and formulating such peptides, and a small molecule drug starts to look much more attractive

In other clinics, patients on PTC treatments have been referred for neuropsychiatric evaluations, and these give much more quantifiable and objective data