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Compared to acute patients, we noted 495 metabolites were significantly reduced but 167 metabolites were elevated in the plasma of LC patients ( Figure 2I )

A second study of individuals from various European countries with mild Graves orbitopathy found that treatment with selenium at 100 ug twice daily for six months led to improvement of orbitopathy in 61% of participants, as compared with pentoxifylline 600 mg twice daily or placebo, which improved orbitopathy in 35% and 36% of participants, respectively

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This raises concern about the actual implication of IL-37 in endometriosis because TNF- stimulates the proliferation of endometrial cells and favors angiogenesis

Here, we summarize the promising therapeutic targets for SLE therapy, which align with recent developments in understanding the diseases pathogenesis and the diversification of the SLE drug pipeline