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217 Throughout the progression from precancerous lesions to localized tumors and from tumors in situ to metastatic tumors, the metabolic preferences of tumor cells continuously change in response to cellular states and environmental conditions, which are regulated by endogenous signals from tumor cells and signals from the tumor microenvironment

Its activity was expresses as g of GSH/mg of tissue

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Their transition to a reactive state is characterized by profound metabolic alterations, marking a shift from a neuroprotective to a potentially neurotoxic profile