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If you experience gastrointestinal discomfort or indigestion, do not take on an empty stomach

Anal Biochem 2011

Among the several mechanisms proposed in attributing the ability of PPAR ligand in inhibiting leiomyoma cell growth, Houston suggested that the inhibition was mediated by negative cross-talk between ER and PPAR signaling pathway where the activation of PPAR inhibits ER-mediated gene expression (Houston et al., 2003)

Kiani AK, Donato K, Dhuli K, Stuppia L, Bertelli M