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Whitehouse F, Kruger DF, Fineman M et al (2002) A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes

The PPAR class has been graveyarded by trials that looked exactly like this one and turned out to cause heart failure or fractures or fluid retention or all three after a year of human exposure. The PPAR veteran is right that this exact pattern has burned the field before

Du J, Zhu Y, Yang X, Geng X, Xu Y, Zhang M, et al

GLP-1 Medications and Musculoskeletal Health Beyond Zepbound, clinical data on other GLP-1 receptor agonists shows that musculoskeletal complaints are rare but documented in post-market reports

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