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However, when ascorbic acid was added to cells from carpal tunnel syndrome patients, it did not stimulate the normal amount of Type I collagen, and the small amount of Type I collagen that was produced had an abnormally high alpha2(I) to alpha1(I) ratio.[1] Adding vitamin C to the injured cells simply made them produce more abnormal collagen, not normal collagen

The effect of honey on cell cultures have shown to reduce inflammatory mediators such as TNF- , IL-1 , IL-6 and also inhibit TLR4/NFB expression [113]