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The trade-off: a severe side effect on day three of a monthly cycle leaves the patient with 25 more days of drug exposure

Diverse Population Studies: Trials should include diverse patient populations, especially including individuals at risk for obesity-associated comorbidities, to ensure generalizability and to assess efficacy and safety across different subgroups

For patients weighing their options, comparing established treatments such as Mounjaro or Zepbound can offer useful context, since both follow a similar philosophy of gradual, provider-guided pacing rather than an immediate jump to a target level

The 1986 Borden award lecture

A 52-week treatment with tirzepatide (5mg, 10mg, or 15 mg) led to a significant MASH resolution without worsening liver fibrosis compared to placebo (Fig.3)