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When levels are chronically low, the shift tends to be gradual rather than dramatic

Jenkins DJA, Kitts D, Giovannucci EL, Sahye-Pudaruth S, Paquette M, Blanco Mejia S, et al

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Recent studies of global and tissue-specific gene KO mice indicate that IGF-I signaling is more critical in the latter steps of the process, but less in the skeletal patterning

Does vitamin C act as a pro-oxidant under physiologic conditions