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Chronic oxidative stress also causes DNA damage, contributing to genomic instability and mutations, which elevate the risk of malignant transformation and the development of hepatocellular carcinoma in MASLD patients (Arroyave-Ospina et al

B12 is routinely sold in pharmacies, but prescription is needed

Studies in *Obesity Surgery* and *Clinical Endocrinology* document that many patients maintain benefits for years with dose optimization strategies

A major mechanism linking GSH to signal regulation is S-glutathionylation (SSG), a reversible post-translational modification in which GSH forms a mixed disulfide bond with reactive cysteine residues on target proteins

Results can be long-lasting with proper maintenance sessions and sun protection