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General Characteristics of the Participants A structured questionnaire was administered to ascertain general aspects [e.g., age, occupation, marital status, residence, substance use, reasons of substance use (e.g., for pleasure, social use, nervousness, or sadness), physical activity], academic aspects, and stressors in school

Accumulated cellular iron generates cytotoxic hydroxyl radicals (OH) via the Fenton reaction

The disease affects approximately 10% of the global population, with prevalence varying across regions due to differences in age, demographics, socioeconomic status, and access to healthcare (Rovin et al., 2024) and studies have consistently demonstrated a rising prevalence in both developed and developing countries

Diagnosis Vein disorders are not always visible