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The effects of genetically engineered tomato extracts (enriched in anthocyanins) (200) showed that the extract reduced the activation of epithelial cells SAPK/JNK (stress-activated protein kinase/c-Jun NH (2)-terminal kinase) and p38MAPK signaling pathways

In the TME, lactate also programs macrophage immunosuppression: lactate uptake via MCT1 increases H3K18la at the GPD2 promoter, elevating GPD2 expression and enforcing M2 polarization, while lactate-blocking strategies or GPD2 deletion reverse this phenotype [298]