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In turn, phosphorylation of the adaptor proteins insulin receptor substrate 14 (IRS-14) and Shc leads to activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways (Baserga, 2000)

The changes in the glycan of placental villous, caused by excessive ROS, can lead to the decreased level of Gal-9, a type of galectins most expressed at the maternal fetal interface, whose increased levels indicate that the placental cells are susceptible to apoptosis (93)

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10.3171/jns.2002.96.2.0287 J

Gastroenterology 167 , 402404 (2024)