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doi: 10.3389/fbioe.2026.1778916 Received 31 December 2025 Revised 17 February 2026 Accepted 24 February 2026 Published 24 March 2026 Volume 14 - 2026 Edited by Ali Raza, UiT The Arctic University of Norway, Norway Reviewed by Shengyong Geng, Chinese Academy of Sciences (CAS), China Shastri, K.B

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When Kupffer cells become activated in response to ethanol consumption, they release various stimulatory molecules such as prostaglandin E2 (PGE 2 )