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Insulin-like growth factor I enhances collagen synthesis in engineered human tendon tissue

The oral route has made it a practical compound for longer-duration studies investigating the chronic consequences of GHS-R1a activation

All doses below come from published clinical trials, manufacturer guidelines, and established practitioner protocols as of February 2026

Free Radic Biol Med 145:819

In brief, animals ( n = 8 per group, per sex) were placed into individual cages at their standard temperature and photoperiod and allowed to acclimate for at least 72 h prior to the experiment, and data were collected over a 24 h period