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Figure 3 5.1 Mechanisms of action 5.1.1 Reduction of uremic toxins Impaired protein absorption in CKD patients causes an increase in levels of undigested or unabsorbed proteins entering the colon, creating conditions in the gut that promote the growth of proteolytic bacterial species (Bammens et al., 2003

It also affects the frontal lobes, which are critical for decision-making, self-control, and personality