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The ultrathin sections were double-stained with uranyl acetate and lead citrate and then examined under a transmission electron microscope (JEM 1010, Japan) at 60 kV

The high levels of metabolites related to the thiomethyl shunt suggest an excessive production of NAQPI-derived glutathione conjugates (unseen so far in the other individuals)

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That claim holds mechanistically in cell and animal studies

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