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Mechanistically, we reveal that VRK2 inhibition disrupts endoplasmic reticulum (ER)-to-Golgi trafficking of SLC7A11, consequently diminishing GSH biosynthesis and predisposing PC cells to ferroptosis

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As mentioned above, glutathione promotes healthy collagen production

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This macrocyclic constraint restricts conformational flexibility, contributing to the extended biological activity duration observed versus native -MSH